During a discussion with an knowledgeable options trader, I was told the significance of interpreting the "Implied Volatility Skew" for stocks and given a paper to read for homework. To get a basic understanding of Implied Volatility Skew see this link here.
The paper I was told to read was "What Does Individual Option Volatility Smirk Tell Us About Future Equity Returns?" by Yuhang Xing, Xiaoyan Zhang and Rui Zhao. In their paper they show empirically, using their SKEW measure, allowed one to predict future stock returns between 1-4 weeks out. Furthermore they also show that a long-short portfolio based on their SKEW measure can generate alphas of 10+% annualized. This their SKEW measure: